Parameters of poor prognosis in preimplantation genetic testing for monogenic disorders

Abstract STUDY QUESTION What is the likelihood of success a single cycle preimplantation genetic testing for monogenic disorders (PGT-M), measured as cumulative live birth rate (CLBR) and based on various patient demographics? SUMMARY ANSWER For all women aged ≤40 years, CLBR was at least 10% when number oocytes ≥7 (range 10–30%) or 5% ≥3 5–17%). WHAT IS KNOWN ALREADY The significantly associated with embryos clinical outcome in PGT-M. Embryos diagnosed affected that remain without diagnosis cannot be used embryo transfer. size group non-suitable transfer varies between 25% 81%, depending indication. Thus, PGT-M more likely to severely impacted by suboptimal ovarian response, poor fertilization development than conventional IVF/ICSI schemes PGT. DESIGN, SIZE, DURATION This single-centre retrospective comparative cohort study, cycles January 2011 December 2015. A total 2265 were compared 2833 ICSI cycles. principal aim our study identification parameters couples undergoing using multiplex short tandem repeat (STR) markers blastomere biopsy DNA. secondary compare population those PARTICIPANTS/MATERIALS, SETTING, METHODS baseline characteristics group. multiple regression analysis applied account following potential confounding factors: female age, previous ART cycles, oocytes/suitable dosage gonadotrophins stimulation. MAIN RESULTS AND THE ROLE OF CHANCE younger (female age 32.0 vs 34.5 years), had higher (1.1 0.9 cycles) (2367 1984 IU). Per cycle, retrieved (11.8 8.3 oocytes), fewer suitable (1.7 2.8 embryos) lower (29.4% 35.0%). Multiple showed influenced dose In both groups, predicted increased increasing numbers embryos. At two one per could confer an estimated above 10%. By assessing together, it shown ≥10% ≥5% ≥3. LIMITATIONS, REASONS FOR CAUTION Despite large sample size, findings are confined limited confounder adjustment lack specific comparators. WIDER IMPLICATIONS FINDINGS aimed describe treatment, CLBR, demographics. program, need informed prognosis specifically futile. table CLBRs presented this useful tool counselling making reproductive choices. FUNDING/COMPETING INTEREST(S) No funding required there no competing interests. TRIAL REGISTRATION NUMBER N/A.